The canine model of neurogenic bladder and
its urodynamic evaluation
Chen F, Xie H, Liu G, Zhao H, Xu M, Xue H
Department of Peadiatric Urology, Xinhua Hospital, Shanghai Second
Medical University, Shanghai, China
Objective: A canine model of neurogenic bladder was developed and evaluated
by urodynamics.
Methods: 8 female dogs were divided
into 2 groups: suprasacral and infrasacral. Spinal cord was transected at
L6-7 level, and sacral cord was kept intact in suprasacral model while in
infrasacral model it was destroyed completely. The urodynamic studies were
performed in each dog at the time points of preoperation and 6 months
postoperatively in both groups. The parameters were maximal bladder volume
(BV), average bladder compliance (BC), maximal urethral pressure (UP) and
maximal urethral closure pressure (UCP).
Results: After operation the dogs
could never move their tail and keep their hips dry. Their latter limbs
were flaccid paralysed and the abdomens dilated during the first week. But
the activity of the latter limbs in both groups recovered slowly; the
abdominal signs were only improved obviously in suprasacral dogs. In
suprasacral group, BV and BC decreased by 37.78% and 53.33%, respectively,
but UP (by 17.32%) and UCP (by 22.56%) increased significantly. While BV
(by 89.31%) and BC (by 77.71%) of infrasacral dogs in 6 months after
operation were higher than those before operation (P��0.05).
Conclusion: The canine model showed
both clinically and urodynamically the same characteristics as that in the
neurogenic bladder after spinal shock. It can be used as a model in the
research of neurogenic bladder.