2679

APOLIPOPROTEIN E POLYMORPHISM AND PLASMA LIPID, LIPOPROTEIN, APLIPORROTEIN LEVELS IN CHILDREN WITH FAMILY OF CORONARY HEART DISEASE

Xiang W, Zhao SP, Zheng C

People's Hospital of Hainan Province, Haikou, China

Objective: To investigate the distribution of apolipoprotein (apo) E polymorphism and affection of apoE genotypes on plasma lipids in children with family of coronary heart disease (CHD).

Methods: ApoE genotypes were determined by polymerase chain reaction-restricted fragments length polymorphism.

Results: Compared with control group, the frequency of apo ��4 allele was higher in children with family of CHD. It was significantly higher in children whose parents or grandparents at 45 years of age or younger with CHD. In children with family of CHD, The levels of total cholesterol, low density lipoprotein-cholesterol, lipoprotein(a), apoB100, apoE had difference among carrier with apo��2, ��3, ��4 alleles. The children with apo��4 allele had higher levels of total cholesterol, low density lipoprotein-cholesterol, apoB100, and lower levels of apoA I, apoE than those with other apoE alleles. The children with apo��2 allele had lower levels of total cholesterol, low density lipoprotein-cholesterol, lipoprotein(a).

Conclusion: There is abnormality of apoE polymorphisms in children with family of CHD. ApoE polymorphisms may affect plasma lipoproteins metabolism.