THE LEVELS OF SERUM
ANTI-GLIADIN IgG AND ANTIENDOMYSIUM ANTIBODIES IN ATOPIC CHILDREN
Yenigun A,
Demir E, Tanac R, Gulen F, Can D, Kutuk,culer N
Division of Pediatrics Allergy and Respiratory Disease, Department
of Pediatrics, Ege University School of Medicine, Izmir, Turkey
Objective:
Celiac disease (CD) is resulted from
intestinal system to gliadin fraction of gluten from wheat, barley, oats,
rye. It is characterized villous atrophy and typical features of
malabsorbtlon. CD can be found associated with both immunologic and
non-immunologic diseases. The increased incidence of CD in children with
type 1 diabetes mellitus, IgA deficiency, Down��s syndrome suggests possible
immunologic factor in the development of celiac disease. The occurrence of
atopy in CD has been reported whereas the prevalence of CD in atopy has not
yet been established. Aim of study we wanted to investigate the levels of
antigliadin and antiendomysium antibodies in atopic children. Also aim for
that, it has been planned to compare between skin prick test of cereals
polen the cereals of food allergy and the levels of serum antibodies.
Methods: In this study, 60 patients went under skin
prick test with SAY products. Antiendomyslum were tested by indirect
immunofluorescence antigliadin
IgG by ELISA.
Results: Patients were 43.3% asthma, 40% rhinitis, 10%
asthma+rhinitis, 6.7% urticaria. Mean of ages were 11. The mean levels of
antigliadin was 2.48 RU/ml (minimum:2, maximum:20). Antigliadin antibody
was found in asthma 4.30��3.19, in
rhinitis 4.27��3.94, in asthma+rhinitis 3.33��1.55 in urticaria 9.00��7.86. The levels of antiendomysium were negative all of patients.
The cereals prick skin tests were found in asthma 11.5%, in rhinitis 20.9%,
in asthma+rhinitis 33.3%, in urticaria 25% (+++). The prick test against
cereals polen was found 69.2% inasthma, 95.8% in rhinitis, 100% in
asthma+rhinitis, 50% in urticaria (+++) and (++++) positive. Rhinitis and
asthma+rhinitis patients were found statistically significant (X2test
p<0.05).
Conclusion: Antigliadin
and antiendomyslum antibodies especially in atopic disease were not found
significant. In both tests a p value of <0.05 was considered
significant. As a result of this research patient who are sensitive
tocereal food and cereal polen have not been found sensitive enough to
celiac disease screen test antigliadin and antiendomyslum antibodies. These
tests should have been on more patients who are suffering from celiac
disease and atopic disease which might give positive results.