2608

THROMBOCYTOPENIA AND ACUTE COAGULATING DISORDERS IN PATIENT WITH SERIOUS INFECTIONS DISEASES

Do Thi Minh Cam, Nguyen Cong Khanh, Cung Thi Ty

National Institute of Pediatrics (Nip), Hanoi, Vietnam

Objectives:

To study Thrombocytopenia and acute coagulation disorders in patients with serious infections.

Materials and methods:

Platelet count and coagulation disorders were observed in 74 patients under 15 years old, among then 13 cases had septic shock and 61 cases had symptomps of bacterial infections.

-The coagulation status of the patients was messured on the automatic coagulation analyser ACL 100. (PT-fibrinogen-APTT-TT)

-Platelet count was accountered on Hycel-680 machine

-Latex D-Dimer test

Results:

-Thrombocytopenia: 66.2% of cases.

-Prolonged prothrombin time (PT): 68.9% of cases

-Prolonged APTT: 72.8% of cases.

-Prolonged thrombin time (TT): 56.8% of cases.

-F.D.P.>5µg/ml:54.1% of cases

There were 20 patients with Disseminated Intravascular Coagulation

(27% of cases) and 3 patients with acute fibrinolysis (4.1% of cases)

Conclusion:

Almost patients with septic shock and bacterial sepsis have had thrombocytopenia and abnormal coagulation, 27% of cases had DIC and 4.1% had acute fibrinolysis. DIC and fibrinolysis were more frequent in patients with septic shock and bacterial sepsis with positive of blood culture.