ADVERSE
EVENTS FOLLOWING VACCINATION OF TYPHIM VI IN JAKARTA PRIMARY CHILD HEALTH
CLINIC
Hartono Gunardi, Rini Sekartini,
Soedjatmiko, Jeanne-Roos Ticoalu,
Titi
S Sularyo
Bagian
Ilmu Kesehatan Anak FKUI -RSCM
Typhoid
fever is still a community health problem related insufficient hygiene in
developing countries. Preventive measures are improvement of environment
sanitation, personal hygiene, hygienic food handling, and vaccine
administration. Either oral or parenteral typhoid vaccine is to decrease incidence
of typhoid morbidity. Typhim Vi is administered parenterally in children 2
years old or older. Adverse events following vaccination of Typhim Vi in
Indonesian children is limited. This study is to investigate the adverse
events following vaccination of Typhim Vi.
Method. This was a cross sectional
descriptive study. Subjects were
healthy 2 �C 5 years children visited Utan Kayu Baby Clinic during July
2000, or Kiara Family Physician Clinic during August 2000. Both clinics are
located in Jakarta. Ten ml multidose Typhim Vi (hospital packed) was used.
The fourth year pediatric resident administered half ml vaccine
intramuscularly in anterolateral of femoral region. Single disposable
syringe was used ounce only. Adverse events following vaccination were monitored
by using modified Indonesian Vaccine Adverse Events Reporting System.
Results. Total of 196 children were
studied, 55% of them were male. Adverse events following vaccination were
local pain (44%), mild fever (12,7%), high fever (12%), local swelling
(3%), vomiting (0,5%). Symptomatic treatment was given to those children.
Discussion. Adverse events
following vaccination in this study were comparable to the previous
studies. The most frequent adverse events were local pain and fever. Factor
that might play a role in adverse event following vaccination was multidose
vaccine.