90% cells differentiated into lipid accumulating adipocytes in comparison with 61%~73% cells differentiated by treatment with either ASP or insulin. The positive expression of LPL, DGAT mRNA in ASP + insulin group were much intensely than the expression of with ASP or insulin alone. Conclusion: ASP, which is a potent adipogenic agent, enhances the expression of adipose-specific genes as well leads to the acquisition of the differentiated phenotype. ASP may play an important role in obese-genesis. " v:shapes="_x0000_s1026">2367