THE ROLE OF MACROPHAGE INFLAMMATORY PROTEIN �C1�� IN HENOCH-SCHONLEIN PURPURA NEPHRITIS
Huang
D-L��Yi Z-W��He Q-N��Wu
X-C��He X-J
Laboratory of Pediatric Nephrology, The Second Hospital of Xiangya
school of medicine, Central South University, Changsha, China
Objective: To evaluate the role of
MIP-1�� in the pathologic change, clinic manifestation and clinic course in HSPN,
and to demonstrate the hypothesis that MIP-1�� via the chemokine receptors
participate in the pathophysiology of HSPN by recruiting and activating
macrophage.
Methods: 22 cases with HSPN and 12
control case were enrolled. We investigated the presence of MIP-1�� protein
and the infiltration of CD68-positive macrophage in the kidneys.
Result: In HSPN group
MIP-1��-positive cells can mainly be found in tubular epithelial��infiltrated inflammatory
cells in mesangium and interstitial areas. In HSPN group, the
intraglomerular and interstitial CD68-positive or MIP-1��-positive cells in
group with crescent were more than those in group without crescent��P��0.05), and those in group with both proteinuria
and hematuria were more than those in group with either proteinuria or
hematuria��P��0.05) The intraglomerular and interstitial
MIP-1��-positive cells in group
with course less than 3 months
were more than those in group with course more than 3 months(P��0.05).the intraglomerular
and the interstitial CD68-positive cells was correlated well with the
MIP-1��-positive cells, respectively. (r=0.664 P��0.01; r=0.829 P��0.05��
Conclusion:
MIP-1�� plays an important role in the acute phase of HSPN by recruiting and
activating macrophage. MIP-1�� and infiltrating macrophage in renal tissue
were correlated well with the clinicopathological findings in HSPN . The
accumulation and activation of macrophage by MIP-1�� may be one of the major
causes of cellular crescents formation in the early phase in HSPN.