CLINICAL
SIGNIFICANCE OF THE DETERMINATION OF THE IMMUNITY PARAMETERS AND EFFICACY
OF IMMUNOCORRECTING THERAPY IN NON-RHEUMATIC CARDITIS IN CHILDREN
Bakhodirova A.N., Akhmedova D.I., Babadjanova
Z.U.
The First State Medical Institute, The
Republican Research Centre of Emergency Medical Care, Tashkent, Uzbekistan
The
purpose of investigation was to study efficacy of immunocorrecting therapy
in children with inflammatory heart diseases. We have observed 84 children
with nonrheumatic carditis aged from 1 to 15 years. Of them 56 children had
acute form of disease, 12 patients had subacute form of disease and 12 -
chronic disease. Analysis of the associated diseases showed that chronic
tonsillitis was found in 93% of children, acute pneumonia in 14,3%, anemia
in 19% of children, chronic persistent hepatitis in 4%, chronic
cholecyctitis in 12%, chronic pyelonephritis in 4,7%, intoxication of CNS
by hypertensive syndrome in 9,4%, and celiaca in 1,2%. For evaluation of
the general immunoreactivity of these children the complex of specific and
nonspecific indicators was studied which reflected, in the whole, the
levels I and II of the immune status. Investigation of the parameters of
the cellular and humoral immunity in patients with nonrheumatic cardidis
showed a number of characteristic changes such as inhibition of T-rosette
forming, reducing of T helpers as compared with healthy children. The
content of T suppressors had no significant change. Among the main classes
of serum immunoglobulines there was noted increase in level of Ig G and
unreliable fluctuation of Ig M. The authors concluded that inclusion of
immunomodulators into the therapy for nonrheumatic cardidits in children
may be reasonable because chronic carditis developed gradually, slowly on
the background of chronic focal infection and recurrent allergic reactions
due to hypoimmune state in these children.