SERUM MARKERS OF BONE
TURN-OVER IN NEWBORNS
Furmaga-Jablonska W 1, Kulik-Rechberger B 1, Kozlowska M 1,
Kosciesza A 1, Spruch-Stepnik A2
1Department of Paediatrics, Medical University School of Lublin,
Poland
2University Children��s Hospital, Lublin, Poland
Objective: The aim of our study was to establish the
level of C-terminal propeptide Type-I collagen (PICP) as a marker of bone
formation and C-terminal telopeptides of Type-I collagen (CrossLaps) as a
marker of bone resorption in serum of appropriate-for-gestational age (AGA)
newborns.
Methods: The research included 47 AGA newborns �C 32 boys
and 14 girls, born in 26-41 week of pregnancy; 28 of them were full-term
and 19 were preterm. The level of PICP (Metra Biosystem, USA) and
CrossLaps (Osteometer,
Denmark) were assayed with ELISA method. Statistic was performed with
t-Student and Pearson correlation tests. P < 0,05 was regarded as
significant.
Results: In newborns serum mean level of PICP was:
2073,8 �� 555,1 ng/ml and mean
level of CrossLaps was: 17413,8 �� 5932,5 pM/l. There were
no statistical differences in the level of PICP and CrossLaps in boys and
girls, as well as in full-terms and preterms (p>0,05). Serum level of
CrossLapss correlated significantly with birth weight (r=0,39,p<0,05) and length
(r=0,36,p<0,05) as well as with gestational (r=0,37,p<0,05) and
chronological age (r=0,36,p<0,05) of newborns. The negative correlation
was shown for PICP level and gestational age of investigated children (r=
-35,p<0,05). There was no statistical correlation between the PICP and
CrossLapss level in new-borns serum.
Conclusion: Despite the very high level of bone
turn-over there is no proportional correlation between the processes of
bone formation and resorption in newborns.