CLINICAL AND
HAEMODINAMIC EFFECT OF HYDROXYETHIL STARCH SOLUTIONS IN CHILDREN SEPTIC
SHOCK
Veliz PR, Garcia GE, Torres VA, Caballero VC, Marquez M,
Aguilar V
La Raza General
Hospital IMSS, Mexico D.F. Mexico
Objective: Know the
clinical and hemodinamic effect of the early administration of Hydroxyethil
Starch (HAES) in septic pediatric patient, compared with the effect of the
same solution in late septic shock and with patients who received albumin
or dextran 40.
Methods: 69 patients
were studied, 8 groups were formed,(1) 15 patients with early hypodinamic
shock managed with HAES, (2)12 early HAES hyperdinamic shock,(3) 5 patients
with late Other Colloid (OC) volume replacement early hyperdinamic
shock,(4) 9 OC early Hypodinamic shock; (5)7 OC Late Hypodinamic shock,(6)
7 OC Late Hyperdinamic shock,(7) 7 HAES late Hyperdinamic shock,(8) 7 HAES
Late Hypodinamic shock. All of them were measured and compared with
themselves al 0,1and 6 hrs..student t test for independent samples and
pared samples as well as variance one way analysis were used.
Result: Oxygen a/v
difference (O2a/vDif). in group 1 diminished to normal with p<0.01,
group 2, increased O2a/vdif. to normal wit p<0.01, group 3 increased
O2a/vdif with p<0.05 not reaching normal levels, group 4 showed no
statistical difference in three measurements, Group 5: Showed no
statistical difference in three measurements.Group 6: Increased O2a/vdif.
To normal levels but no statistical difference were found. Group 7
increased O2a/vdif. To normal levels with p<0.05. Group 8: diminished
O2a/vDif. With p<0.05. Other than O2a/vDif, we measured and compared,
Heart rate, Capillary refill, Mead arterial Tension, Mix venous oxygen
content, arterial pH, CVP, CI, Swan Ganz catheter measurements. And
mortality. Conclusion: Early
shock management improved better and had less mortality than late shock
management, HAES improved better and had less mortality than other colloid
in early shock.