THE DRUG THERAPY
AND EFFECT ON THE UPPER GASTROINTESTINAL HEMORRHAGE OF NEWBORN
Lu
Ling
Guangzhou Children's Hospital, Guangzhou, China
Objective: To explore the joint effect of proton
pump inhibitor Omeprazole and exogenous glutamine (Marzulene-SGranules) on
the upper gastrointestinal hemorrhage of newborn.
Methods: All the newborns were divided into therapeutic
group consisting of 27 newborns and routine group consisting of 35
newborns. The therapeutic group was treated by joint method: i.e.Omeprazole
and Marzulene-S Granules, while the routine group was treated with Dicynone
and Thrombin. The mean staunching days of two groups were compared.
Results: There was significant difference in the mean
staunching days between therapeutic and routine groups (t=4.493,P<0.001)
.The difference also existed in the hypoxia and non-hypoxia subgroup of
routine group (t=2.686,P<0.05).
Conclusion: There was severe reversed diffusion of
hydrogen ions into gastric mucosa of the upper gastrointestinal hemorrhage
of newborn caused by stessing conditions such as asphyxia��hypoxia��infection etc. Combining
with acid inhibitor Omeprazole and gastric mucosa restoring agent
Marzulene-S Granules, We can attain remarkable and stable effect on the
upper gastrointestinal hemorrhage of newborn.