THE STATES OF��FUNCTION OF T CELLS��AND ROLES OF��CYCLOSPRINE A IN CHILDREN WITH

HENOCH-SCHONLEIN PURPURA

LI Q, Yang X-Q, LI Y-B, Wang L-J

Children��s Hospital, Chongqing University of Medical Science��Chongqing��Chain

Objective: To observe the states of��function of T cells and to investigate the roles of Cyclosporin A(CsA) in T cells in the children with Henoch-Schonlein purpura(HSP) in the��acute phase.

Methods: The cells count of CD30 expression in Peripheral blood mononuclear cell(PBMC) were determined by flow cytometry. IgA, IgG, IgM, IgE��Ig subsets and cytokines were detected by radial immunodiffusion and ELISA.

Results: The serum IgA and IgE levels, and IgG subsets, IgE, IL-4 and IL-5 levels in the supernatants of cultured PBMC of HSP patients were increased significantly in contrast to the normal controls. IL-2 and IFN-��were decreased. The raised of IL-5 and IL-4 in the supernatants of cultured PBMC of HSP patients were related to the increased of IgA����=0.63��and IgE����=0.87�� in serum. The leveals of high TH2 cytokines such as IL-4,IL-5 and IL-6could be affected by CsA in vitro. The TH1 cytokines further were inhibited.

Conclusions: the dysfunction of T cell were related to the pathogenesis of HSP patients. The inhibition of CsA on T cells function of HSP patients were showed. To inhibited TH1 function mainly.

Address: Zhongshan 2rd 136��Yuzhong District, Chongqing��China 400014

Tel: 0086-023-63622554 (o)

0086-023-68725352 (o)

E-mail: xuliqiu@yahoo.com