SHORT-TERM
STOSSTHERAPY BY METHYLPREDISOLONE(MPSS) IN CHILD PATIENTS WITH SEVERE
ASTHMA(AFFILIATED WITH ANALYSIS OF EIGHTEEN CASES)
Zhang R-Y
Children��s
Hospital, Chongqing University of Medical Sciences, Chongqing, China
Objective: To study the
outcome of short-term stosstherapy by mpss in child - patients with severe
asthma.
Methods: All thirty-two
patients who had severe asthma were selected in accordance with the
diagnostic standard of asthma and randomly enrolled into two groups. In the
mpss group (n=18), the dose of mpss was 2-4mg/kg, q8h also for three days,
while in the control group(n=14), dexamethasone was administered
intravenously with 0.5~0.75mg/kg, q8h also for three days. Other treatments
were the same in two groups.
Results: After three-day
treatment, in mpss group, there was a shorter time of duration of cough,
wheezing and stridor than that in control group and the results of P were
<0.01,<0.05 and <0.05, respectively. There were significantly
better results in Pao2, Paco2, PH and PEFR (P<0.01). But in control
group, no significant changes were found in Paco2, PH and PEFR except Pao2
with a few changes (P>0.05)
.
Conclusion: Asthmatic is a kind of allergic
disease with inflammation in airway. Glucocorticoids is the most effective
medication administered to diminish airway inflammation. The commonly-used
glucocorticoids include dexamethasone, hydrocortisone and mpss. Our data
demonstrates that mpss is better than dexamethasone in anti-inflammation
and bronchochilation for child patients with severe asthma which is the
best choice of glucocorticoids to treat severe asthma.