PROTECTIVE EFFECT OF MILD HYPOTHERMIA ON HYPOXIA-ISCHEMIC BRAIN DAMAGE

Jiang Chunming, Mi Yan

The First Hospital of Harbin Medical University, Harbin, China

 

Objectives: The aim of this study is to examine the protective effect of mild hypothermia on hypoxia-ischemic brain damage (HIBD) in the neonate and to define the optimal therapeutic window of hypothermia.

Methods: The HIBD model was produced in the traditional model of neonatal hypoxia-ischemic (HI) which subjected 7-old-day Wistar rats to unilateral carotid artery ligation followed by an hypoxic (8% oxyger) episode of 2 hours duration. The rats were divided into five groups randomly. Group��: sham-operated. Group��:No treatment was applied to animal after hypoxic-ischemic onset. Group ��:4 hours of hypothermia was applied to animal at 30 minutes after the hypoxic-ischemic onset. Group ��:hypothermia was applied at 1 hours after hypoxic-ischemic onset. Group ��:hypothermia was applied at 3 hours after the hypoxic-ischemic onset. The homogenate of cortical cells was used to determine malonyldialdehyde (MDA) content and superoxide dismutase (SOD) activities. Apoptosis neuronal cell was observed by terminal deoxynucleotidyl transferase mediated dUTP-biotin nick end labelling(TUNEL) staining and bax gene expressing.

Results: The MDA content was 170.25 �� 17.00; 325.78 �� 10.77; 244.02 �� 17.07; 298.95 �� 14.74; 312.22 �� 14.57 (mean �� standard error of the mean, n = 15 per group) for ��.��.��.��.��groups respectively. The SOD activities for these five respective groups were 31.69��3.30; 51.23��3.10; 60.63��3.38; 53.47��2.45; 52.22��1.91 (mean �� standard error of the mean,n = 15 per group). The MDA content of group �� was significantly lower than group��.��.��(p<0.01). The number of  apoptosis cell for ��.��.��groups was 18.80��1.37; 15.53��0.64; 19.53��0.92 (mean��standard error of the mean,n = 15 per group). The number of the cell that expressed bax gene was 35.87��1.64; 29.13��1.81; 36.20��1.47(mean��standard error of the mean, n = 15 per group). Contrast with group��,apoptosis cell of group �� was significantly lower(p<0.01), but group �� has no difference with group ��,moreover the apoptosis cell of group �� was higher than group �� obviously(p<0.01).

Conclusions :These results demonstrated that hypothermia prevented hypoxic-ischemic brain damage by suppressing the generation of free radicals and the apoptosis of cells; the optimal therapeutic window of mild hypothermia was within the 30 minutes after the onset of hypoxic-ischemic.

 

 
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