PARENTAL ATOPIC DISEASES IN ASTHMA CHILDREN

J. Minov¹, E. Vlaski², I. Sokolovski¹, Z. Stojanovski¹

¹Health Center Skopje, ²University Children's Hospital Skopje, R. Macedonia

Background. Atopy, as a genetic predisposition for IgE mediated response, represents a strong factor in asthma etiology, that is 65-75% of asthmatic children and 50-60% of asthmatic adults are atopics. Atopy and asthma are genetically heterogenous, involving several different genes or gene groups, with enviromental factors moderating role.

Objective: Survey of corelation between childhood asthma and parental atopic diseases.

Patients and methods: We have investigated parental history of atopic diseases in 57 asthma children, 39 boys and 18 girls, mean age 84,63 months. The prevalences were statistically done by means of Chi-square test.

Results: Parental atopic diseases were found in 22 asthma children (38,7%), that is in 16 boys (41,1%) and 6 girls (33,3%). The corelation between prevalences done by means of Chi-square test was non significant (p = 0,297). In 8 cases (14,1%) atopic disease was presented in fathers, in 9 cases it was presented in mothers (15,7%), while in 2 cases (3,4%) it was presented in father and mother. Parental extrinsic asthma was presented in 6 cases (10,5%). The most frequent atopic diseases presented in fathers were hay fever and alimentary urticaria and the most frequent diseases presented in mothers were extrinsic asthma and insect venom urticaria.

Conclusion: Our data have shown high, but statistically non significant association between childhood asthma and parental phenotype atopy.

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