ABNORMALITY OF GROWTH HORMONE-INSULIN-LIKE GROWTH FACTOR AXIS IN CHILDREN WITH NEPHROTIC SYNDROME AND ITS SIGNIFICANCE

Zhang JY¹, Huang Xiaoyan², Yang Jianhui¹

¹Jinan General Military Hospital, Jinan, China

²Qilu Hospital, ShanDong University, Jinan, China

Objective: To investigate the effect of growth hormone-insulin-like growth factor axis on the height of children with nephrotic syndrome (NS).

Methods: We tested the serum concentrations of growth hormone (GH ) , insulin-like growth factor-1 (IGF-1), insulin-like growth factor-2 (IGF-2) and insulin-like growth factor binding protein-3 (IGFBP-3) in 46 children with NS by Radioimmunology assay.

Results: There were significant differences in GH, IGF-1, IGF-2 and IGFBP-3 between mesangial proliferative glomerulonephritis (MesPGN), focal glomerulosclerosis (FGS), membranous glomerulonephritis (MGN) and controls (P<0.01). After the drug incentive test, there were 18 cases in the maximal levels of GH less than 10.0ug/L, in which there were 16 cases with non-minimalchange disease and 67% patients with various degrees of renal failure and disease course more than 10 months. However, there were 23 cases in MCD with the maximal levels of GH more than 10.0ug/L.

Conclusions: There is a correlation between the abnormality of GH-IGF axis and nephrotic pathyologic kind, disease course and renal function. IGFs and IGFBP-3 is a major mark in diagnosis of the abnormal GH-IGF axis resulting in growth obstraction.

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