0954

HEPATITIS B VIRUS-ASSOCIATED GLOMERULONEPHRITIS WITH HEPARIN BY SUBCUTANEOUS INJECTION

Jin T, Xie Y-Z

Department of Pediatrics, Taijiang Hospital, Fuzhou, Fujian, China

Objective: To study the effective cure in the treatment of hepatitis B virus-associated glomerulonephritis (HBV-GN).

Methods: Subcutaneous injection of heparin was used to treat 13 sick children clinically and pathologically diagnosed as HBV-GN. Among them were 11 males and 2 females, aged from 1 10/12 to 12 years old, with disease course from 3 days to 4 years. In clinical manifestation, 4 cases had proteinuria and hematuria, 3 cases nephrotic syndrome, 3 cases acute nephritic syndrome, 2 cases asymptomatic proteinuria and 1 case simple hematuria. Pathologic pattern: 9, MN, 4, FSGS, 2, MsPGN, 2, ECPGN. The usage of heparin: 250-375 IU/kg daily, two times a day, subcutaneous injection, and each treatment course was 3 months.

Result: 7 cases of them received only heparin treatment. As a result, 6 cases received effectual result, and 1 case responded to it. 4 sick children with nephritic syndrome and large proteinuria were given extra prednisone 2 months after heparin treatment, resulting in two effectual cases. One of the two received repeated renal biopsy, showing improvement of lesion. And the other two did not respond to it. At the beginning of heparin treatment, 3 cases received extra interferon for 3 months. As a result, 1 case showed effectual result (with prednisone at the same time), and the other 2 received good result. However, after interferon treatment, serum HBV antigen remained unchanged. The result of the 13 cases treated: 8 obviously effectual result (62%), 3 effectual result (23%), 2 without effect (15%).

Conclusion: Subcutaneous injection of heparin results in certain curative effect on HBV-GN in different disease courses and different pathologic patterns. This is a better method in the treatment of HBV-GN at present.