EFFECT OF IRON DEFICIENCY ANEMIA ON
LEARNING AND MEMORY ABILITY AND BRAIN TRACE ELEMENTS IN RATS
Hu R-M, Wei M-W, Sun R-P, Zhang Y.
Department of Pediatrics, Qilu Hospital
of Shandong University
Objective: To investigate the effect of iron deficiency anemia (IDA) on
learning and memory ability and its biochemical basis in rats.
Methods:
The iron deficiency anemia animal model was made by feeding the rats a low
iron content diet (11.9mg/kg). The learning and memory ability was tested
by means of MG-2 model maze. The contents of 7 kinds of trace element in
brain were determined by DCP-AES technique.
Results: The rats of experimental group needed more training to reach the
learning criterion. The brain iron (Fe) and zine (Zn) contents of
experimental group were markedly lower than those of control group. The
manganese (Mn) and cadmium (Cd) contents of experimental group were
markedly higher than those of control group.
Conclusions: It is suggested that IDA rats had learning and memeory defects
that may attribute to abnormal metabolism of trace elements in brain.