IMMUNOLOGIC
ABNORMALITIES IN ACUTE Guillain-BARR
syndrome PATIENTS OF DIFFERENT CLINICAL PATTERNS
Wu M1, Cai F-C2
1 Chengdu
Children's Hospital, Chengdu, Sichuan, China
2 Children's
Hospital, Chongqing Medical University, Chongqing, China
Objective: To study the impact of
immunologic abnormalities on pathogenesis of acute Guillain-Barr�� syndrome
(GBS) patients with acute motor axonal neuropathy (AMAN) and acute
inflammatory demyelinating polyneuropathy (AIDP).
Methods: The cytokines, IgG
production in the serum and cultured supernatants of peripheral blood
mononuclear cells (PBMCs) from 12 AMAN, 9AIDP patients and 16 age-matched
healthy controls were measured.
Results: The cytokine levels of
interleukin (IL)-2 in the serum and IL-2, IL-6, tumor necrosis factor
(TNF)-��, IgG in the PBMC supernatants of AMAN and AIDP group and TNF-��in the serum
of AMAN group were statistically higher than those in controls (q=3.0~7.5,
p<0.05 or 0.01).
Furthermore, the level of TNF-��in the PBMC supernatants
of AMAN was obviously higher compared with the AIDP group
(q=3.78,p<0.05). Serum IgG, IgA, IgM and IgG subclasses were elevated in
13 patients.
Conclusions: There were a T cell
immunity abnormality and a polyclonal
B cell activation in AMAN and AIDP patients. The TNF-��may play an
important role in the pathogenesis of AMAN patients.