A
RESEACHOR OF MUTUALITY OF ENPOTHELIN AND NITRIC OXIDE IEVELS IN PLASMA OF
NEWBORN INFANTS WITH HYPOXIC ISCHEMIC ENCEPHALOPATHY
Zhao
Ling, Chen Xiao, Liu Tao
Department
of Pediatrics, First Affiliated Hospital, Jiangxi Medical Mollege, Nanchan,
China
Objective:
To study the relationship and the changes of
endothelin-1 (ET-1) and nitricoxide (NO) in plasma on hypoxic ischemic
encephalopathy (HIE).
Methods: In 36 newborn infants with HIE (11 cases of mild, 15 cases of
moderate and 10 cases of severe status), EF-1 levels in plasma were
measured by radio immunoassay both in land 5 days; No2-/No3-
level of plasma were measured with nitrate reductase.
Results: In 1day, the ET-1 levels of plasma in infants with severe HIE
were much higher than those in controls, especially the severe cases. There
was no significant difference of ET-1 levels between the mild HIE and the
control infants. However, in 5day, the ET-1 in severe HIEinfants kept at
the high level. In 1day the NO levels in plasma of the moderate and severe
HIE infants were much higher than those of controls. The NO levels of the
severe HIE infants were obviously higher than those of the mild ones. In
5day, the NO level in all three groups of HIE infants decreased to the
normal levels, which were no significant differences in compared with the
control.
Conclusion: The brain damage of HIE infants might relate to the over
expression of ET-1 and NO. It can be taken as an index to judge the state
of illness and prognosis.