THE RESEARCH INTO CHILDREN WITH CHLAMYDIA
Fu WY, Cheng HJ, Lu JR
First Hospital, Jilin University,
Changchun, China
Objective:
Based on the fact that the relatively high
incidence of chlamydia trachomatis (CT) and chlamydia pneumonia (CP) ,and
it has been becoming the focus of
recent research. We carried out a series of studies on children
infected with CT and CP to interpret the actual status of CP infection in
Changchun district and to testify the vertical transmission from mother to
the child, then to discuss the clinical deteting methods of chlamydia.
Methods: Three
groups were investigated by the prospective method from 1993 to 1997: CT
isolation from NPS of 49 children with pneumonia by HeLa -229 cell, CT
genomic type was deter- mined from 106 mothers and their children. With the
method of restriction fragment length polymorphism, CP isolation from NPS
of 87 children with pneumonia.
Results:
9 of HeLa-229 cells isolation groups were
positive, and its positive rate was 18.4 %, most of them were under the age
of 6 months, accompanied CT-IgM elevation; among PCR group 26 of 106
pregnant mothers were CT positive, and their children were 11/106, among
correspondence of mothers to children were 10 cases. The same CT genomic
type was identified between mothers and their children by PCR��RFLP. The vertical transmission
rate was 38.5%. The genomic type were E of 5, D of 2, F of 2, J of 1 respectively.
11 of Hep-2 culture group were positive, and its positive rate was 12.6%,
of 10 positive cases had elevated CP-IgG/IgM.
Conclusion: Chlamydia is one of the most pathogens of children with
respiratory infection in Changchun district, and there is vertical
transmission from mothers to children, so we should pay attention to the
clinical, diagnostic and treatment research of chlamydia infection.