Association of beta2- adrenergic receptors gene
polymorphisms with asthma in the children of southern China
Liao W, Li W-M, Zhao C-M��Guang L-X��Xi-M
Xinqiao Hospital, Third Military Medical University,
Chongqing, China
Objective��To investigate the association between��2-adrenergic
receptors(��2-AR) gene polymorphisms and asthmatic severity.
Methods��The genotypes of loci 16 and 27 of the b2-AR were detected by using PCR
and restriction fragment analysis in 50 asthmatic children, 100 healthy
controls from the Han nationality of southern China. Meanwhile, the
asthmatic children were classified as intermittent ��mild��moderate��and severe subgroups according
to their clinical characters.
Results: There were no significant increases in the frequency of
glycine(Gly)16/Gly and Glutamic acid(Glu)27/Glu genotypes in the asthmatic
children compared with healthy controls(0.19 vs 0.22,0.12 vs 0.18
respectively, P>0.05).but there were significant increases in the
frequency of Gly16/Gly genogype in the severe asthma subgroup compared with
the mild(0.67 vs 0.07, p<0.05)�� moderate subgroups(0.67 vs
0.12, p<0.05).
Conclusions:
The ��2-AR gene polymorphisms were not
determinant of pathogenesis of asthma, but the b2-AR 16 locus polymorphisms is
possibly correlated with asthmatic severity in the children of the Han
nationality of southern China.