0481

EFFECT OF INHALED BUDESONIDE AND FORMOTEROL IN TREATING MODERATE PERSISTENT CHILDREN ASTHMA

Xu LL, Ling XY, Hua XL

Union Hospital, Fujian Medical University, Fuzhou, China

Objective: To evaluate the effects of adding formorterol to Inhaled budesonide (BUD) in treating moderate persistent children asthma.

Methods: Fifty patients with moderate persistent asthma were randomly divided into two groups: inhaled BUD 200��g/d qd plus formoterol tablets 4 ��g/kg.d bid in groups��and inhaled BUD 400��g/d qd in groups��, treatment Continued for 3 months. The efficacy between groups��and groups�� were compared by symptoms scores , PEF% predicted and daily PEF Variability(PEFV %).

Results: Symptoms scores ( 2.6��0.4 vs 1.3��0.7 in group��, 2.7��0.3 vs 1.4��0.6 in groups��), and lung function (PEF % 70.2��4.8% vs 99.3��5.4 % in group��71.6��4.5% vs 101.8��8.6 % in group �� and PEFV% 34.1��3.4% vs 21.7��4.3% in group��33.6��3.2% vs 22.0��.38% in group ��) had obvious difference between the patients before treatment and those after treatment three months (P<0.01, respectively), the improvements with formoterol were greater after treatment one month (p<0.05). But the total effective rates in both groups were alike��100% vs100%��after treatment 3 moths.

Conclusion: In symptomatic children with moderate asthma (especially for nighttime symptoms) taking low to moderate doses of inhaled steroids, the therapy of adding the long-acting ��₂-agonist may replace that therapy of alone increasing corticosteroids dosage.