0465

EVOLUTION OF CLINICAL AND FUNCTIONAL ESPIRATORY MANIFESTATIONS IN ADOLESCENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

Furuya MEY¹, Barajas MA¹, Guerra J¹, Vargas MH¹, Catal��n T¹, Esp��nola-Reyna GA², Mar��n JC¹

¹Hospital de Pediatr��a, ��CMN SXXI��, IMSS, Mexico D.F.

²Hospital de Cardiolog��a, ��CMN SXXI��, IMSS, Mexico D.F.

Objective: To determine the frequency, type of alterations and evolution of respiratory clinical manifestations and pulmonary function tests (PFT) in adolescents with systemic lupus erythematosus (SLE).

Patients: Adolescents with SLE seen at the Rheumatology clinic. Demographic, clinical and radiological data were collected, and PFT (plethysmography, DL_CO) and pulse oximetry were performed at baseline conditions and one year later. Student's t test and Pearson's correlation coefficient were done.

Results: Twenty-three patients aged 12-18 years (14.7��1.5, mean��SEM), 18 women (78%), with evolution time of 2.9��1.8 years (range 0.3-6.5) were included in this study. None required hospitalizations for respiratory causes. Dyspnea (11 patients) and cough (6) were the most frequent symptoms. Chest radiographs were normal except in 3 patients (pleural effusion 1, cisuritis 2). The first PFT determination was normal in 13 patients (56%), obstructive in 7 (30%), restrictive in 1 (4%), and with mixed pattern in 2 (9%). The main abnormal variable was FEF75. DL_CO was normal excepting in 1 patient. One year later, symptoms were less, PFT were normal in 14 patients (60.8%), obstructive in 6 (27%), and with mixed pattern in 3 (13%), without statistically significant differences.

Conclusion: Alterations of PFT were frequent in this population, almost without clinical or radiological manifestations. There was no correlation between PFT and evolution time or symptoms. Taking into account previous reports in the literature, our population presented a different pattern of respiratory manifestations.