0438
FORMING OF NEPHROPATHIES
IN CHILDREN LIVING IN CONDITION OF TOXIC LOADING Sarsenbaeva S, Mazhitova Z,
Sultanculova G Kazakh State Medical
University, Almaty, Kazakhstan Objective: Examination of children from region of the
Aral Sea ecological catastrophe set of renal system pathology in
54,1%.� Methods: The prevalence of dysmetabolic violations
in diseases structure (49,9%) in the form of oxalic nephropathy as display
of membrane destructive process, permitted to use modern method of early
diagnostic of pathological changes in the kidneys - an enzymatic activity
definition of urine. The enzymes level of different subcell-like
localisation (alkaline phosphatase, γ-glutamiltransferase, sodium
lactatum dehydrogenase(SLD), aspartataminotransferase, alaninaminotransferase)
was studied. Results: Detection of different changes in kidneys
in 1,5 times more (81,4%) than when using a custom diagnostic methods.
Syndromes of enzymatic insufficiency of canaliculies epithelium (53,6%) and
damages of �brush edging of epithelium
of nephron proximal canaliculies (17,3%), which are main regulator of homeostasis.� Conclusion: lowering of SLD in 2,5 times are the sign
of deep exchange dystrophyc violations in cells of children's organism at
constant toxic loading. Aforesaid changes in enzymatic activity of urine
are result of chemical toxic substances influence on cells membranes of
children�s kidneys→to violation of antioxidant protection and
destruction of membranes phospholipids with accumulation of nitrous
components in tissues→to oppression of synthetic and regenerating
activity of cells, by main result which one are appearance an atypical
kidneys diseases for children and early aging of organism, which were
diagnosed in children living in the Aral Sea region.