0436

interstitial damages of lung tissue in children living in Aral Sea region

Mazhitova Z

Kazakh State Medical University, Almaty, Kazakhstan

Objective: Aim of investigation � study some processes in lung tissue in children, who died from diseases connected not with pathology of respiratory system.

Methods: Autopsy material was investigated: preparations of lung tissue of children in age to 2 years old � 51,8%, in age 2-5 years old - 15,5%, in age 5-7 years old - 13,7%, in age more 7 years old - 19%.

Results: Macroscopic picture of lungs was characterized, in most observations, by bars of lung tissue, cloudy of connective tissue around small bronchial tubes and vessels. Emphysematous expansion in field of lungs tops were detected in some cases, small cysts were discovered in lung tissue, on account of lung tissue had �cellular� condition. Pre-root lymphatic glands, big pea size, had black color on the section. These changes testified about connection between lung tissue pathology and T-cell-bound immunity activity. Results of microscoping of authopsy preparats detected some changes, which are typical for different stages of alveolitis. Thickening of the intralveolar partitions due to overgrowth of connective tissue was discovered in lung tissue. Diffusive alveolitis was diagnosed in 35,48% cases, disorganization of alveolar structures � 45,16%, �honeycomb lung� � 19,36%.

Conclusion: Analysis of pathologoanatomical study of lung tissue from children lived in region of ecological catastrophe � Aral Sea region � had detected prevalence interstitial damages of lungs as fibrosis alveolitis.