0336

THE CHANGES OF INSULIN LIKE GROWTH FACTOR-I��IGF-I�� AND IGF BINDING PROTEINS DURING GLUCOCORTICOID TREATMENT IN CHILDREN WITH NEPHROTIC SYNDROME

Dong F*, Zhou X*, Pang N*, Wei M**

* China-Japan Friendship Hospital, Beijing, P. R. China

** Beijing Union Hospital, Beijing, P. R. China

Object: In this study, we tried to find out the changes of serum IGF-I and Insulin-like growth factor binding proteins (IGFBPs) in nephrotic syndrome (NS) and the effect of glucocorticoid on serum IGF-I and IGFBPs. This may be some helpful for finding out the reason and benefit to the prevention of growth retardation in NS.

Method: We measured the serum IGF-I and IGFBPs level of 36 children with nephrotic syndrome by RIA and IRMA, including: active stage group ��ANS, n=12��, remission stage group (RE, n=12), active stage group with glucocorticoid treatment (GNS, n=12) and normal control group (NC, n=10).

Result: 1) Comparing with normal control (NC)�� serum levels of IGF-I and IGFBP-3 were decreased��54��9 vs 306��38��1631��286 vs 3854��384��P<0.01) in ANS group; serum levels of IGFBP-1 and IGFBP-2 were increased (231��38 vs 152��16��3299��389 vs 866��90��P<0.01); 2��Serum levels of IGF-I and IGFBP-3 in RE Group were higher than that in ANS Group (484��107 vs 54��9��4967��532 vs 1631��286�� P<0.01) ��IGFBP-1 and IGFBP-2 were lower than that in ANS Group (101��17vs 231��8��671��56 vs 3299��389��P<0.01)��3��Comparing with ANS group�� serum levels of IGF-I and IGFBP-3 were increased in GNS group (310��47 vs 54��9 ; 3619��282 vs 1631��286,P<0.01); serum levels of IGFBP-1 and IGFBP-2 were decreased respectively (154 ��20 vs 231��8;1573��197 vs 3299��389��P<0.01); 4��A correlation was found between serum levels of IGFBP-3 and Albumin in active stage��r=0.76, P<0.01) ; and a correlation between serum levels of IGF-I and IGFBP-3 and there was a inverse correlation between serum level of IGF-I and serum levels of IGFBP-1 and IGFBP-2 in ANS group, Any correlations in other groups could not be found.

Conclusion�� 1��The serum levels of IGF-I and IGFBPs can be changed in active stage of children NS, but return to normal in remission stage; 2��Glucocorticoid treatment may have a influence on serum IGF-I and IGFBPs in NS; 3)The changes of IGF-I and IGFBPs may play a role in the growth retardation of NS children.