0233

A COMPARATIVE STUDY ON THE EFFICACY OF EARLY INTERVENTION BETWEEN THE BRAIN CT AND DEVELOPMENT QUOTIENT IN THE NEONATAL HYPOXIC ISCHEMIC ENCEPHALOPATHY

Zhang XF, Zhou DY, Gao HJ, Zhang Y, Li M, Liu GH�

Harbin Children�s Hospital, Harbin, China

Objective: To explore the efficacy of early intervention on the newborns suffered from hypoxic ischemic encephalopathy (HIE) through a series of follow-up cases, which were examined the development quotient (DQ) and the brain CT, and evaluate early prognosis of the neonatal HIE.

Methods: One hundred survivors suffered from neonatal HIE (II, II - III) which received early intervention, were followed up for two years and examicied CT and DQ.

Results: 1. An early intervention was carried for improving the prognosis of the newborns with HIE(II, II - III), The normal rate of their brain CT and DQ in early intervention group were higher than no-intervention group. These differences were statistically significant, P<0.01. There were no significant differences in neonatal HIE (III), P>0.05. 2.The follow-up examination showed that the high correlation between the brain CT and DQ in early intervention group, r=0.88. The brain CT in early intervention group was improved, accompanied by the improvement of clinical signs (DQ level). Meanwhile, the low correlation between the brain CT and DQ in no-intervention group, r=0.55.

Conclusion: Early intervention can improve clearly the prognosis of neonatal HIE. CT integrated with DQ can improve accuracy and early diagnosis.