THE
TREATMENT OF INFECTIOUS BRAIN EDEMA IN CHILDREN BY CHINESE HERBAL MEDICINE ��EXPERIMENTAL STUDY��
Yu
PL, Zhang BL, Yue SJ
Department of
Pediatrics, Xiang Ya Hospital, Center Southern University, Changsha, China
Objective: This paper
includes 8 subgroup studies to evaluate the effect and mechanism of several
Chinese herbal medicines for the treatment of infectious brain edema.
Methods:
All subgroups were randomly divided into experimental and control
groups. Name of drugs �� Injection of Ligusticum wallichi Franch and carthamus
tinctorius, �� Tetramethylpyrazine, �� Anisodamine
Hydrochloride, �� Baicalin, �� Qingkailing, were
injected for the treatment of infectious brain edema models. Three kind of infectious
brain edema animal
models were used.
Model I was induced by pertussis bacilli, model II was induced by E.Coli,
and model III was induced by glutamic acid.
Results: In model I:
Drug �� reduced the injury of blood brain barrier and
its permeability. Drug �� and �� reduced the content of brain water, sodium
and Evan��s blue, reduced the intracranial pressure (ICP) and improved the
pathological changes of brain tissue. Drug �� and �� facilitated
the production of HSP70. In compared with mannitol, the reduction of ICP of
�� and �� were slower
but persisted for a longer duration. The pathological changes of brain
tissue were significantly improved of �� and �� in compared
with the control and mannitol groups. Drug �� reduced the water as
well as the glutamate content of the brain. In model II: drug �� reduced the
content of endotoxin, TNF��, TXB2 of CSF, reduced the water
content of brain and improved the pathological change of brain tissuce. Drug
�� reduced both
the water and glutamate content of the brain and reduced the endotoxin,
lactic acid and MDA in CSF. In model III: Drug �� reduced the
brain edema and the Ca2+ content of the synapse of brain, the number of
NMDA of cell membrane of brain were reduced too.
Conclusion: The above
studies showed that all the above 5 drugs were effective for the treatment
of brain edema in the experimental animal models. These results might
induce a kind of new treatment for clinical infectious brain edema.