0143

IS THE CESSATION OF BRONCHIAL OBSTRUCTIVE ATTACKS RELATED TO A LOSS OF ALLERGIC SENSITIZATION?

Vlaski E¹, Sarafiloska J², Hristova M¹, Nikolovski Lj¹, Minov J³,

Sazdovski A1

1. Clinic of Pediatrics, 2. Clinic of Dermatovenerology, 3. Health Facility, Skopje, R. Macedonia

Objective: The aim of the study was to examine if the cessation of obstructive attacks in atopic patients was related to a loss of allergic sensitization.

Methods: A selected group of 30 children suffering from atopic asthma was prospectively followed up until their obstructive attacks stopped at least for a period of 1 year (all 4 seasons). Allergic sensitization was established by UniCAP-FEIA specific IgE to common aeroallergens (Pharmacia, Uppsala, Sweden) in the whole group at the beginning of the study and after the cessation of obstructive attacks in 15 patients.

Results: All 15 patients with a cessation of obstructive attacks remained hypersensitive to at least one of the investigated aeroallergens. Specific hypersensitivity (SH) to grass pollens has been changed and become negative only in 1/15 patients (8/15 positive patients at the beginning and 7/15 at the end of the study). Sensitivity to tree and weed pollens has been changed in none of the patients and remained negative. SH to D. pteronyssinus has not been changed in any of the patients and remained present. However, its degree has been changed in 3/15 patients (in two patients it became smaller and in one bigger) (Fisher test p>0.05). SH to house dust has been changed and become negative only in 2/15 patients (8/15 positive patients at the beginning and 6/15 at the end of the study).

Conclusion: It seems that the cessation of obstructive attacks in atopic asthma is not related to the loss of allergic sensitization.