0084

HIGH-FREQUENCY OSCILLATORY VENTILATION IN NEWBORN INFANTS WITH RESPIRATORY FAILURE

Liu XH, Huang HJ, Li CR

Children Hospital of Shenzhen 518026, China

Objective: To assess ventilation strategies, survival and complications in 18 newborn infants treated with high frequency oscillatory ventilation (HFOV).

Methods: From October 1998 to December 1999,18 of infants with respiratory failure, who were unresponsive to optimal conventional ventilation and pharmacological therapy and received HFOV (Sesormedical 3100A)were retrospectively evaluated.

Results: Sixteen of 18 patients (88%) were survived. The best surviving rates were infants with meconium aspiration syndrome (7/7), pulmonary interstitial emphysema with air leak (5/5), and infants of birthweight >1500g with hyaline membrane disease (2/3). Two infants who had severe multify organ function failure were deteriorated using HFOV, and died after 62 hours. Complications including: infants in weighting <1500g developed ventricular hemorrhage (2), pulmonary interstitial emphysema (1) and hypotension (1).

Conclusion: HFOV to newborn infants with respiratory failure is encouraging ventilation mode in decreasing mortality and complications.