0030

BMC ACCRETION AND DETERMINATION OF SERUM BGP AND ALP DURING PUBERTY

Li J-B, Li H-Q, Wang S-Y, Hu Y

Children's Hospital of Chongqing University of Medical Sciences, Chongqing, China

Objective: This cross sectional study is to determine the rate of bone mineral content (BMC) accretion at the radius position and its relations to pubertal stages and linear growth in a group of healthy children and adolescents aged 9~20 yr.

Methods: The BMC were assessed by single photon absorptiometer. Serum bone Gla protein (BGP) and alkline phosphatase (ALP) were determined using radioimmunodetection and biochemistry methods respectively. Pubertal stages were assessed using the criteria from Tanner.

Results: Positive correlation between BMC and age was observed in both sexes. In females compared to males, BMC accretion was earlier with a reduction after16 yr. The accretion of BMC was highly correlated with pubertal stages. Serum BGP correlated positively with ALP, the timing of peak serum BGP/ALP and PHV were coincident, preceding the peak BMC accrual.

Conclusion: This study demonstrated the close association between BMC and age or pubertal stages. There was an asynchrony between the BMC accrual and linear growth.