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RELATION BETWEEN ELECTROENCEPHALOGRAPHIC DYSMATURITY PATTERN AND CEREBRAL BLOOD FLOW IN HIGH RISK NEONATES

Safaa A.E Hamid EL Meneza, Neonatal Unit, Faculty of Medicine for Girls, AL Azhar University, Cairo, Egypt.

Objective: High-risk newborn infants are liable to neurological complications, which may impair their motor, sensory and cognitive development. The objectives of this work, was to study the relation between cerebral haemodynamics using Doppler technique and the dysmaturity EEG pattern in high-risk neonate.

Subjects and Methods: The study population consisted of two groups, group I normal control (12), and group II, (120) high- risk infants .All cases were subjected to routine care, cranial ultrasound and Doppler blood flow (CBF) in ACA&MCA at 12,24, and 48 hours of age. Initial EEG was done to all cases. Survival cases were followed till six months of age.

Results: Dysmaturity pattern was diagnosed in (36.6%) have HIE cases. Transient dysmaturity pattern was seen in (13.3%) as the infants showed latter a pattern corresponding to their postnatal age. Permanent dysmaturity pattern was diagnosed in (23.3%) of HIE cases. Accelerated and delayed form was seen. CBF increased in infants with transient pattern, while infants with permanent dysmaturity had shown a luxury hyper perfusion. This change was seen in ACA and MCA in full tem and preterm infants in 12,24,48 hours.

Conclusion: Changes in cerebral blood flow and loss of cerebral auto regulation can lead to dysmaturity EEG pattern in neonates with HIE.